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This contrasts with a strong positive correlation between cord blood IGF-I concentrations and birth size

3.5 Meta-analysis The included studies showed substantial heterogeneity (I 2 = 99.6%, p 0.05), supporting the conclusion of comparable efficacy and the lack of a clear doseresponse relationship

Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR

That makes it a much milder and safer option for recovery and performance enhancement

In SURMOUNT-5, GI adverse events leading to treatment discontinuation were 5.6% for semaglutide vs 2.7% for tirzepatide, suggesting a possible tolerability advantage for tirzepatide in that trial context